Application of Molecular Modelling Techniques to Pheromones of the Marine Brown Algae Cutleria multifida and Ectocarpus siliculosus (Phaeophyceae). Metalloproteins as Chemoreceptors?

نویسنده

  • Wilhelm Boland
چکیده

The conformation o f the two algal pheromones ectocarpene (1) and multifidene (2) was studied by the active analogue approach using molecular mechanics calculations within the software package SYBYL. A common conformation for both pherom ones and all active analogues was filtered out by superpositionand energy minimizing procedures starting from crystallographic data of the Cambridge Structural Data Base (CSD). The interaction of the algal receptor systems with their olefinic pherom ones and heteroanalogues is in excellent agreement with the assumption of a receptor-bound metal cation acting as the binding side.

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تاریخ انتشار 2013